Route 66 Casino
Sportsbook Review

Route 66 Casino Hotel sits on Albuquerque's west side, perched on Central Avenue at the historic Route 66 corridor and operated by the Pueblo of Laguna. Its location — an exit off I-40 — makes it the most convenient legal NM sportsbook for travelers heading to or from Arizona, Gallup, or the Four Corners region. For Albuquerque West Side residents, it's roughly 20 minutes from downtown.

The book itself runs on USBookmaking, the same operator powering Santa Ana Star and Buffalo Thunder, so bettors will recognize the odds boards and ticket flow. Markets cover the major American sports plus boxing, soccer, golf, and NASCAR, with selected player props and live in-game betting. The lounge is more compact than what you'd find at Isleta or Buffalo Thunder, but the upside is far smaller crowds — even on big NFL Sundays or UFC pay-per-view nights.

Route 66 also leans into its travel-stop identity. The 154-room hotel, on-site travel center, RV parking, and concert venue make it a natural overnight stop for road-trip bettors. In-state college rules follow the broader NM pattern: Lobos and Aggies game lines are typically posted, but individual prop bets on NM college athletes are off the board.